Understanding how neutrophils leave inflamed tissues to help resolve arthritis
Official title: Mechanisms of Reverse Transendothelial Migration in Arthritis Resolution
Funded at University of Missouri-Columbia · NIH-10951303 · Data updated 2026-11-12
This study is looking at how certain white blood cells called neutrophils help reduce inflammation in conditions like arthritis, with the goal of finding new ways to help heal tissues and improve treatments for people dealing with chronic inflammation.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | September 24, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $366,797 |
| NIH project number | 1R21AR084708-01 |
| Project ID | NIH-10951303 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic inflammatory diseases such as arthritis or asthma.
✕Less likely to help
Patients with acute infections or those not experiencing chronic inflammation may not benefit from this research.
What this research studies
This research investigates the mechanisms behind reverse transendothelial migration (rTEM) of neutrophils, which play a crucial role in resolving inflammation associated with conditions like arthritis. By studying how neutrophils exit inflamed tissues, the research aims to uncover new pathways that could enhance the resolution of inflammation and promote tissue healing. The approach involves examining the interactions between neutrophils and endothelial cells, focusing on the processes that lead to effective inflammation resolution. Patients may benefit from insights gained that could lead to improved treatments for chronic inflammatory diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance the resolution of inflammation, potentially improving outcomes for patients with arthritis and other inflammatory conditions.
How similar studies have gone: Previous research has shown promise in understanding inflammation resolution mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Missouri-Columbia
Columbia, United States Active
Researchers
- Principal investigator: Brown, Charles R. — University of Missouri-Columbia
- Study coordinator: Brown, Charles R.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.