Understanding how neutrophils contribute to liver disease caused by alcohol
Mechanism of neutrophilic NCF1 in alcohol-associated liver disease pathogenesis
['FUNDING_CAREER'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-10901910
This study is looking at how a type of immune cell called neutrophils affects liver damage in people with alcohol-related liver disease, hoping to find new ways to help those who are struggling with this condition.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-10901910 on ClinicalTrials.gov |
What this research studies
This research investigates the role of neutrophils, a type of immune cell, in the development and severity of alcohol-associated liver disease (ALD). The study aims to uncover the mechanisms by which neutrophils mediate liver injury, particularly focusing on the production of reactive oxygen species (ROS) and the involvement of the NCF1 gene. By examining patient samples and animal models, the researchers hope to identify specific patterns of neutrophil behavior that correlate with disease severity. This could lead to new insights into how to better manage or treat patients suffering from alcohol-related liver conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with alcohol-associated liver disease or those experiencing severe alcohol-related liver conditions.
Not a fit: Patients who do not have alcohol-associated liver disease or those with liver conditions unrelated to alcohol consumption may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with alcohol-associated liver disease by targeting the mechanisms of neutrophil involvement.
How similar studies have performed: Previous research has shown that targeting immune cell mechanisms can lead to significant advancements in understanding and treating liver diseases, suggesting a promising avenue for this study.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MA, JING — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: MA, JING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alcoholic Liver Diseases