Understanding how neutrophils contribute to liver disease caused by alcohol
Official title: Mechanism of neutrophilic NCF1 in alcohol-associated liver disease pathogenesis
Funded at Indiana University Indianapolis · NIH-10901910 · Data updated 2026-11-12
This study is looking at how a type of immune cell called neutrophils affects liver damage in people with alcohol-related liver disease, hoping to find new ways to help those who are struggling with this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | August 8, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $147,202 |
| NIH project number | 5K99AA031067-02 |
| Project ID | NIH-10901910 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with alcohol-associated liver disease or those experiencing severe alcohol-related liver conditions.
✕Less likely to help
Patients who do not have alcohol-associated liver disease or those with liver conditions unrelated to alcohol consumption may not benefit from this research.
What this research studies
This research investigates the role of neutrophils, a type of immune cell, in the development and severity of alcohol-associated liver disease (ALD). The study aims to uncover the mechanisms by which neutrophils mediate liver injury, particularly focusing on the production of reactive oxygen species (ROS) and the involvement of the NCF1 gene. By examining patient samples and animal models, the researchers hope to identify specific patterns of neutrophil behavior that correlate with disease severity. This could lead to new insights into how to better manage or treat patients suffering from alcohol-related liver conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with alcohol-associated liver disease by targeting the mechanisms of neutrophil involvement.
How similar studies have gone: Previous research has shown that targeting immune cell mechanisms can lead to significant advancements in understanding and treating liver diseases, suggesting a promising avenue for this study.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Ma, Jing — Indiana University Indianapolis
- Study coordinator: Ma, Jing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.