Understanding how neutrophils contribute to inflammation in sepsis
Mechanisms regulating neutrophil proinflammatory activity in sepsis
This study is looking at how a type of white blood cell called neutrophils behaves during sepsis, a serious infection, to find new ways to help patients recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11050264 on NIH RePORTER |
What this research studies
This research investigates the role of neutrophils, a type of white blood cell, in the inflammatory response during sepsis, a severe condition caused by infection. The study aims to uncover the molecular mechanisms that regulate neutrophil activity and their interactions with other blood components, which can lead to tissue damage and organ failure. By exploring these mechanisms, the researchers hope to identify new therapeutic strategies to improve treatment outcomes for patients suffering from sepsis.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing sepsis or are at high risk for developing this condition.
Not a fit: Patients who are not adults or those with conditions unrelated to sepsis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for sepsis, potentially reducing mortality and improving recovery for affected patients.
How similar studies have performed: Previous research has shown promising results in understanding neutrophil behavior in inflammatory conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Cho, Jaehyung — Washington University
- Study coordinator: Cho, Jaehyung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.