Understanding how neutrophils contribute to inflammation in sepsis
Official title: Mechanisms regulating neutrophil proinflammatory activity in sepsis
Funded at Washington University · NIH-11050264 · Data updated 2026-11-12
This study is looking at how a type of white blood cell called neutrophils behaves during sepsis, a serious infection, to find new ways to help patients recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | January 24, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $479,249 |
| NIH project number | 1R01AI181792-01A1 |
| Project ID | NIH-11050264 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are experiencing sepsis or are at high risk for developing this condition.
✕Less likely to help
Patients who are not adults or those with conditions unrelated to sepsis may not benefit from this research.
What this research studies
This research investigates the role of neutrophils, a type of white blood cell, in the inflammatory response during sepsis, a severe condition caused by infection. The study aims to uncover the molecular mechanisms that regulate neutrophil activity and their interactions with other blood components, which can lead to tissue damage and organ failure. By exploring these mechanisms, the researchers hope to identify new therapeutic strategies to improve treatment outcomes for patients suffering from sepsis.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for sepsis, potentially reducing mortality and improving recovery for affected patients.
How similar studies have gone: Previous research has shown promising results in understanding neutrophil behavior in inflammatory conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Cho, Jaehyung — Washington University
- Study coordinator: Cho, Jaehyung
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.