Understanding how neutrophils contribute to inflammation in cystic fibrosis lungs
Extracellular vesicle-driven neutrophilic inflammation in cystic fibrosis lungs
This study is looking at how a type of white blood cell called neutrophils causes lung inflammation in people with cystic fibrosis, and it hopes to find new ways to help improve their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10875571 on NIH RePORTER |
What this research studies
This research investigates the role of neutrophils, a type of white blood cell, in causing inflammation in the lungs of cystic fibrosis (CF) patients. It aims to uncover how these cells behave and interact with their environment, particularly focusing on their recruitment and function in CF lung disease. By using advanced models that mimic human airway conditions, the study will explore the mechanisms behind neutrophil-driven inflammation and how extracellular vesicles influence this process. The ultimate goal is to identify new treatment strategies that could improve outcomes for individuals with CF.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with cystic fibrosis, particularly those experiencing chronic lung inflammation.
Not a fit: Patients without cystic fibrosis or those with other unrelated respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that better manage inflammation in cystic fibrosis, potentially improving lung function and quality of life for patients.
How similar studies have performed: Previous research has shown promising results in understanding neutrophil behavior in other inflammatory conditions, suggesting that this approach may yield valuable insights for cystic fibrosis as well.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Tirouvanziam, Rabindra Marie-Jean — Emory University
- Study coordinator: Tirouvanziam, Rabindra Marie-Jean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.