Understanding how neutrophils contribute to heart damage after blood flow restoration
Very early drivers of neutrophilic inflammation in cardiac ischemia-reperfusion
This study is looking at how certain immune cells called neutrophils can cause heart problems after blood flow is restored following a heart attack, and it aims to find ways to help the heart heal better by blocking some of these cells' actions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11074586 on NIH RePORTER |
What this research studies
This research investigates the role of neutrophils, a type of immune cell, in causing inflammation and damage to the heart following ischemia-reperfusion injury, which occurs when blood flow is restored after a heart attack. By using advanced techniques like single cell RNA sequencing, the study aims to identify different types of neutrophils and their functions in this process. The researchers will also explore how inhibiting specific pathways related to these cells can improve heart recovery. This work could lead to new treatments that target neutrophil activity to protect the heart after such injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a heart attack and are undergoing treatment for ischemia-reperfusion injury.
Not a fit: Patients with chronic heart conditions unrelated to ischemia-reperfusion injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that minimize heart damage and improve recovery after heart attacks.
How similar studies have performed: Previous research has shown promising results in targeting neutrophil activity to reduce inflammation in other conditions, suggesting potential success for this approach.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Levit, Rebecca Diane — Emory University
- Study coordinator: Levit, Rebecca Diane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.