Understanding how neutrophils contribute to breast cancer spread
Identifying the pro-metastatic mechanisms of neutrophil extracellular traps
This study is looking at how certain immune cells might help breast cancer cells wake up and spread after treatment, and it aims to find ways to stop this from happening, which could help patients avoid cancer coming back.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11080367 on NIH RePORTER |
What this research studies
This research investigates the role of neutrophil extracellular traps (NETs) in the spread of breast cancer after initial treatment. It focuses on how dormant cancer cells can become active again and how inflammation in the body can support this process. By studying mouse models, the researchers aim to identify the mechanisms that allow these cancer cells to proliferate and how the inflammatory environment is created. This could lead to new strategies to prevent metastatic recurrence in breast cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who have been treated for primary breast cancer and are at risk for metastatic recurrence.
Not a fit: Patients with metastatic breast cancer who are currently undergoing treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the recurrence of breast cancer by targeting the mechanisms of metastasis.
How similar studies have performed: Previous research has shown that targeting inflammatory processes can be effective in managing cancer metastasis, indicating potential for success in this approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Egeblad, Mikala — Johns Hopkins University
- Study coordinator: Egeblad, Mikala
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.