Understanding how neutrophils change in autoimmune diseases
Neutrophil plasticity in autoimmune disease
This study is looking at how a type of immune cell called neutrophils behaves in autoimmune diseases like rheumatoid arthritis and lupus, to find new ways to help improve treatments for people living with these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10764907 on NIH RePORTER |
What this research studies
This research investigates the role of neutrophils, a type of immune cell, in autoimmune diseases such as rheumatoid arthritis and lupus. It explores how these cells can change their function and potentially contribute to organ damage when activated by certain antibodies. By studying the mechanisms behind neutrophil activation and their transformation into other immune cells, the research aims to uncover new therapeutic targets that could improve treatment outcomes for patients with autoimmune conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autoimmune diseases like rheumatoid arthritis or lupus.
Not a fit: Patients with non-autoimmune conditions or those not experiencing significant immune system involvement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more targeted therapies that reduce organ damage and improve the quality of life for patients with autoimmune diseases.
How similar studies have performed: Previous research has shown promising results in understanding neutrophil behavior in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Mayadas, Tanya N — Brigham and Women's Hospital
- Study coordinator: Mayadas, Tanya N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.