Understanding how neurotrophins affect hearing in the brainstem
Official title: Uncovering the Functional Effects of Neurotrophins in the Auditory Brainstem
Funded at Northwestern University · NIH-10934348 · Data updated 2026-11-12
This study is looking at how a special protein called BDNF helps the brain develop and work better for hearing, which could lead to new ways to help people with auditory processing disorders.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | January 1, 2024 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $44,187 |
| NIH project number | 5F31DC021366-02 |
| Project ID | NIH-10934348 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with auditory processing disorders or related auditory perceptual issues.
✕Less likely to help
Patients with purely mechanical hearing loss or those without auditory processing challenges may not receive benefit from this research.
What this research studies
This research investigates the role of neurotrophins, specifically Brain-derived neurotrophic factor (BDNF), in the development and functionality of the auditory brainstem. By examining how these proteins influence the growth and organization of neurons, the study aims to uncover their effects on sound processing and localization. The research will utilize advanced biological assays to analyze the signaling pathways involved and their impact on auditory neuron properties. Patients with auditory processing disorders may benefit from insights gained through this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for auditory processing disorders, improving patients' ability to understand and localize sounds.
How similar studies have gone: Previous research has shown that neurotrophins play a critical role in neuronal development, suggesting that this approach could yield significant insights into auditory processing.
Where this research is happening
-
Northwestern University
Chicago, United States Active
Researchers
- Principal investigator: Mclellan, Kristine — Northwestern University
- Study coordinator: Mclellan, Kristine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.