Understanding how neurotrophins affect hearing in the brainstem
Uncovering the Functional Effects of Neurotrophins in the Auditory Brainstem
['FUNDING_FELLOWSHIP'] · NORTHWESTERN UNIVERSITY · NIH-10934348
This study is looking at how a special protein called BDNF helps the brain develop and work better for hearing, which could lead to new ways to help people with auditory processing disorders.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY (nih funded) |
| Locations | 1 site (Chicago, UNITED STATES) |
| Trial ID | NIH-10934348 on ClinicalTrials.gov |
What this research studies
This research investigates the role of neurotrophins, specifically Brain-derived neurotrophic factor (BDNF), in the development and functionality of the auditory brainstem. By examining how these proteins influence the growth and organization of neurons, the study aims to uncover their effects on sound processing and localization. The research will utilize advanced biological assays to analyze the signaling pathways involved and their impact on auditory neuron properties. Patients with auditory processing disorders may benefit from insights gained through this research.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with auditory processing disorders or related auditory perceptual issues.
Not a fit: Patients with purely mechanical hearing loss or those without auditory processing challenges may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for auditory processing disorders, improving patients' ability to understand and localize sounds.
How similar studies have performed: Previous research has shown that neurotrophins play a critical role in neuronal development, suggesting that this approach could yield significant insights into auditory processing.
Where this research is happening
Chicago, UNITED STATES
- NORTHWESTERN UNIVERSITY — Chicago, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCLELLAN, KRISTINE — NORTHWESTERN UNIVERSITY
- Study coordinator: MCLELLAN, KRISTINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acoustic Perceptual Disorder, Auditory Comprehension Disorder, Auditory Perceptual Diseases, Auditory Perceptual Disorders, Auditory Processing Disorder