Understanding how neurotransmitter transporters work and their interaction with drugs
Functional Dynamics of Neurotransmitter:Sodium Symporters (NSSs)
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10826268
This study is looking at how certain proteins in our brain help move important chemicals like serotonin and how different medications can change their behavior, which could lead to better treatments for conditions like ADHD.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10826268 on ClinicalTrials.gov |
What this research studies
This research investigates the functional dynamics of neurotransmitter:sodium symporters (NSS), which are crucial for the transport of neurotransmitters like serotonin. By employing a combination of functional, spectroscopic, and computational methods, the study aims to uncover how these transporters operate, particularly focusing on how psychoactive drugs influence their activity. Patients may benefit from insights gained about the mechanisms of drug action and potential new therapeutic targets for conditions like ADHD. The research emphasizes the importance of understanding the structural changes and dynamics of these transporters in relation to drug binding and transport processes.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals diagnosed with ADHD or related conditions that involve serotonin dysregulation.
Not a fit: Patients with conditions unrelated to neurotransmitter transport or those not affected by serotonin levels may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions like ADHD by enhancing our understanding of how drugs interact with neurotransmitter transporters.
How similar studies have performed: Previous research has shown success in understanding neurotransmitter transport mechanisms, suggesting that this approach may yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: QUICK, MATTHIAS — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: QUICK, MATTHIAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Attention deficit hyperactivity disorder