Understanding how neurotransmitter transporters work and their interaction with drugs
Official title: Functional Dynamics of Neurotransmitter:Sodium Symporters (NSSs)
Funded at Columbia University Health Sciences · NIH-10826268 · Data updated 2026-11-12
This study is looking at how certain proteins in our brain help move important chemicals like serotonin and how different medications can change their behavior, which could lead to better treatments for conditions like ADHD.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 12, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $631,373 |
| NIH project number | 1R01MH134473-01A1 |
| Project ID | NIH-10826268 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals diagnosed with ADHD or related conditions that involve serotonin dysregulation.
✕Less likely to help
Patients with conditions unrelated to neurotransmitter transport or those not affected by serotonin levels may not receive benefit from this research.
What this research studies
This research investigates the functional dynamics of neurotransmitter:sodium symporters (NSS), which are crucial for the transport of neurotransmitters like serotonin. By employing a combination of functional, spectroscopic, and computational methods, the study aims to uncover how these transporters operate, particularly focusing on how psychoactive drugs influence their activity. Patients may benefit from insights gained about the mechanisms of drug action and potential new therapeutic targets for conditions like ADHD. The research emphasizes the importance of understanding the structural changes and dynamics of these transporters in relation to drug binding and transport processes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions like ADHD by enhancing our understanding of how drugs interact with neurotransmitter transporters.
How similar studies have gone: Previous research has shown success in understanding neurotransmitter transport mechanisms, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Quick, Matthias — Columbia University Health Sciences
- Study coordinator: Quick, Matthias
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.