Understanding how neurotensin affects decision-making in cocaine addiction
Determining how neurotensin mediates valence processing and compulsive cocaine seeking
This study is looking at how a brain chemical called neurotensin affects our feelings about cocaine, helping us understand why some people might keep seeking it even when it’s harmful, which could lead to better ways to treat addiction.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11013928 on NIH RePORTER |
What this research studies
This research investigates the role of neurotensin in how the brain processes positive and negative feelings related to cocaine use. By studying specific brain regions involved in reward and avoidance behaviors, the research aims to uncover the neural mechanisms that influence compulsive drug-seeking behavior. The approach includes examining how neurotensin affects decision-making in response to both rewarding and punishing cues. This could lead to new insights into addiction treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with cocaine addiction or those who have a history of substance use disorders.
Not a fit: Patients who are not addicted to cocaine or do not have a history of substance use disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for treating cocaine addiction by targeting the brain's valence processing mechanisms.
How similar studies have performed: Previous studies have shown promising results in understanding the neural mechanisms of addiction, suggesting that this approach may yield valuable insights.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Li, Hao — Northwestern University at Chicago
- Study coordinator: Li, Hao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.