Understanding how neuropilin-2 affects immune responses in organ transplants
Neuropilin-2 in Alloimmunity
This study is looking at how a protein called neuropilin-2 affects the immune system, especially in people who have had organ transplants, to find ways to help their bodies accept the new organs better and reduce the chances of rejection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10784702 on NIH RePORTER |
What this research studies
This research investigates the role of neuropilin-2 in the immune response, particularly in the context of organ transplants. It focuses on how this receptor influences the activation of CD4+ T cells, which are crucial for the body's response to foreign tissues. By examining the mechanisms of immunoregulation and the effects of neuropilin-2 on immune cells, the study aims to uncover new strategies to improve graft survival and reduce transplant rejection. Patients may benefit from insights that could lead to better management of transplant outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals undergoing or considering organ transplantation.
Not a fit: Patients who are not candidates for organ transplantation or those with stable grafts may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing organ transplant rejection, enhancing graft survival rates.
How similar studies have performed: Previous research has shown promising results in understanding the role of neuropilin-1 in immunity, suggesting that exploring neuropilin-2 may also yield significant insights.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Briscoe, David M. — Boston Children's Hospital
- Study coordinator: Briscoe, David M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.