Understanding how neurons transport important molecules for their health and function
Investigating the Role of Neuronal SYNJ2 in mRNA Transport and Mitochondrial Function
['FUNDING_OTHER'] · NEW YORK UNIVERSITY · NIH-10877207
This study is looking at how a protein called Synaptojanin 2 helps move important materials around in brain cells, which is especially important for keeping them healthy and functioning well, and it could help us understand more about diseases like Alzheimer's and Parkinson's.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10877207 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protein called Synaptojanin 2 (SYNJ2) in the transport of mRNA and mitochondrial function within neurons. Neurons require a constant supply of energy and proteins to maintain their complex functions, and this study focuses on how SYNJ2 helps transport essential components to the farthest parts of the neuron. By examining the mechanisms of mRNA transport and its impact on mitochondrial health, the research aims to uncover new insights into neuronal function and survival, particularly in the context of neurodegenerative diseases like Alzheimer's and Parkinson's.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neurodegenerative diseases, particularly Alzheimer's disease or Parkinson's disease.
Not a fit: Patients with acute neurological injuries or those not diagnosed with neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurodegenerative diseases by improving our understanding of neuronal health and function.
How similar studies have performed: Other research has shown promising results in understanding mitochondrial function and mRNA transport in neurons, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GIBBS, WHITNEY SHAREE — NEW YORK UNIVERSITY
- Study coordinator: GIBBS, WHITNEY SHAREE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease