Understanding how neurons produce and release different types of vesicles that carry important signals.
Official title: Exploring how cells generate and release distinct subpopulations of dense-core vesicles
Funded at University of Washington · NIH-10820499 · Data updated 2026-11-12
This study is looking at how brain cells create and release tiny packages that carry important chemicals like dopamine and norepinephrine, which are key to our mood and mental health, to help us better understand mood disorders and other neurological issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | April 15, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $194,375 |
| NIH project number | 5R21NS129149-02 |
| Project ID | NIH-10820499 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing mood disorders or other related neurological conditions.
✕Less likely to help
Patients with purely physical health issues unrelated to neurological or mood disorders may not benefit from this research.
What this research studies
This research investigates the mechanisms by which neurons generate and release dense-core vesicles, which are small organelles that transport crucial neurotransmitters like dopamine and norepinephrine. By examining how these vesicles are formed, what they carry, and how they are released, the study aims to uncover the biological processes that underlie various mood disorders and neurological conditions. The research employs advanced imaging techniques to visualize these vesicles and their contents, providing insights into their role in regulating behavior and mental health.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for mood disorders and other neurological conditions.
How similar studies have gone: While the specific mechanisms of dense-core vesicle function are not fully understood, related research has shown promise in understanding neurotransmitter release and its implications for mental health.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Ailion, Michael — University of Washington
- Study coordinator: Ailion, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.