Understanding how neurons maintain their structure and function
Official title: In situ cryo-EM of protein condensates in the early secretory pathway of neurons
Funded at University of California, San Diego · NIH-10985181 · Data updated 2026-11-12
This study is looking at how brain cells keep their shape and function properly, which is really important for sending and receiving signals, and it aims to help us understand what goes wrong in diseases like Alzheimer's.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $238,500 |
| NIH project number | 1R21DA061421-01 |
| Project ID | NIH-10985181 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with neurodegenerative diseases, particularly those exhibiting symptoms of Alzheimer's disease.
✕Less likely to help
Patients with non-neurodegenerative conditions or those without cognitive impairments may not benefit from this research.
What this research studies
This research investigates the mechanisms by which neurons maintain their polarity, which is crucial for their ability to receive and transmit signals. It focuses on the biosynthetic processes that ensure essential cargo, such as receptors and channels, are correctly delivered to specific parts of the neuron. By using advanced imaging techniques, the study aims to visualize the organization and routing of these cellular components in real-time. This could provide insights into the cellular dysfunctions that occur in neurodegenerative diseases like Alzheimer's.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating neurodegenerative diseases by restoring neuronal function.
How similar studies have gone: Other research has shown promising results in understanding neuronal function and disease mechanisms, indicating that this approach has potential for success.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Ernst, Andreas Max — University of California, San Diego
- Study coordinator: Ernst, Andreas Max
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.