Understanding how neurons maintain their structure and function
In situ cryo-EM of protein condensates in the early secretory pathway of neurons
['FUNDING_R21'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-10985181
This study is looking at how brain cells keep their shape and function properly, which is really important for sending and receiving signals, and it aims to help us understand what goes wrong in diseases like Alzheimer's.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10985181 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which neurons maintain their polarity, which is crucial for their ability to receive and transmit signals. It focuses on the biosynthetic processes that ensure essential cargo, such as receptors and channels, are correctly delivered to specific parts of the neuron. By using advanced imaging techniques, the study aims to visualize the organization and routing of these cellular components in real-time. This could provide insights into the cellular dysfunctions that occur in neurodegenerative diseases like Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neurodegenerative diseases, particularly those exhibiting symptoms of Alzheimer's disease.
Not a fit: Patients with non-neurodegenerative conditions or those without cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating neurodegenerative diseases by restoring neuronal function.
How similar studies have performed: Other research has shown promising results in understanding neuronal function and disease mechanisms, indicating that this approach has potential for success.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ERNST, ANDREAS MAX — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: ERNST, ANDREAS MAX
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease