Understanding how neurons influence the development of low-grade brain tumors.
Neuronal Regulation of Low-Grade Gliomagenesis
This study is looking at how brain cells influence the growth of low-grade brain tumors in kids with Neurofibromatosis type 1, using mouse models to find new ways to treat these tumors while minimizing side effects from current treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11054668 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which neurons regulate the formation and progression of low-grade gliomas, particularly in children with Neurofibromatosis type 1 (NF1). By studying preclinical mouse models that mimic human optic pathway gliomas, the researchers aim to uncover how changes in neuronal activity can affect tumor initiation and growth. The approach involves manipulating the activity of retinal ganglion cells to see how it impacts glioma development, with the goal of identifying potential therapeutic targets. This work is crucial for improving treatment strategies and reducing the neurotoxic effects associated with current therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include children diagnosed with Neurofibromatosis type 1 who are at risk for developing optic pathway gliomas.
Not a fit: Patients without Neurofibromatosis type 1 or those with high-grade gliomas may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for low-grade gliomas that minimize long-term cognitive side effects.
How similar studies have performed: Previous research has shown promising results in understanding the role of neuronal signaling in tumor biology, suggesting that this approach could yield significant insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Monje-Deisseroth, Michelle — Stanford University
- Study coordinator: Monje-Deisseroth, Michelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.