Understanding how neurons control protein synthesis for brain function
New mechanisms and technologies for understanding post-transcriptional gene regulation in neurons
This study is looking at how brain cells manage the production of proteins that are important for learning and memory, especially in people with fragile X syndrome, and aims to find new ways to help improve their cognitive development.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11093328 on NIH RePORTER |
What this research studies
This research investigates the complex mechanisms by which neurons regulate protein synthesis, which is crucial for brain functions like learning and memory. The focus is on understanding how RNA modifications influence the fate and function of messenger RNA (mRNA) in neurons. The research also explores the role of RNA in fragile X syndrome, a genetic condition that affects cognitive development, and aims to develop new treatment strategies based on these findings. By creating innovative technologies for analyzing RNA in the brain, the research seeks to uncover new insights into neuronal function and disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with fragile X syndrome or related neurodevelopmental disorders.
Not a fit: Patients with neurological conditions unrelated to RNA regulation or fragile X syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurological conditions like fragile X syndrome, improving outcomes for affected patients.
How similar studies have performed: Other research has shown promise in understanding RNA regulation in neurological conditions, suggesting that this approach could yield significant insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Jaffrey, Samie R — Weill Medical Coll of Cornell Univ
- Study coordinator: Jaffrey, Samie R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.