Understanding how neurons control mitochondria at nerve terminals
Mitochondrial Interactions with the Plasmamembrane: Genetic Underpinnings and Functional Consequences at Drosophila Nerve Terminals
This study is looking at how nerve cells in fruit flies take care of their energy-producing parts, called mitochondria, to help them work properly and send messages in the brain, and it aims to understand how different types of nerve cells do this.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-11159255 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which neurons manage mitochondria at their nerve terminals, which are crucial for energy production and neurotransmitter release. By using the fruit fly Drosophila, researchers will explore how mitochondria interact with the plasma membrane and how these interactions differ among various neuron types. The study employs advanced imaging techniques to visualize these interactions and their genetic foundations, aiming to uncover the significance of mitochondrial function in maintaining healthy neural activity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodegenerative disorders or those interested in the genetic factors affecting neuronal health.
Not a fit: Patients with acute neurological injuries or conditions unrelated to mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into neurodegenerative diseases and potential therapeutic strategies to enhance mitochondrial function in neurons.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial function in neurons, suggesting that this approach could yield valuable insights.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: Macleod, Gregory Talisker — Tulane University of Louisiana
- Study coordinator: Macleod, Gregory Talisker
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.