Understanding how neurons connect and communicate in the brain
Official title: Mechanistic studies of molecular recognition and signaling of neuronal wiring receptors
Funded at University of Chicago · NIH-11101380 · Data updated 2026-11-12
This study is looking at how brain cells connect and talk to each other, which is really important for how our brains work and how we behave, and it could help us learn more about conditions like autism where these connections might not work properly.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | June 4, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $490,273 |
| NIH project number | 5R01NS139060-02 |
| Project ID | NIH-11101380 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autism spectrum disorder or related neurodevelopmental conditions.
✕Less likely to help
Patients with neurodevelopmental disorders not related to synaptic connectivity or those without a diagnosis may not benefit from this research.
What this research studies
This research investigates the mechanisms behind how neurons form connections and communicate with each other, which is crucial for proper brain function and behavior. By studying specific proteins involved in these processes, the research aims to identify new ways that neurons interact and signal to one another. The approach combines biochemical techniques and genetic analysis to uncover the complex networks that guide neuron connectivity. This knowledge could help in understanding neurodevelopmental disorders, such as autism, where these processes may be disrupted.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential treatments for neurodevelopmental disorders like autism.
How similar studies have gone: Previous research has shown success in identifying neural receptor interactions and their roles in brain development, suggesting that this approach has the potential for meaningful discoveries.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Ozkan, Engin — University of Chicago
- Study coordinator: Ozkan, Engin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.