Understanding how neurons communicate through electrical signals
CRCNS: Mechanistic Modeling and Inference of Neuronal Synaptic Transmission
['FUNDING_R01'] · UNIVERSITY OF DELAWARE · NIH-10426127
This study is looking at how brain cells send messages to each other and how different factors, like timing and randomness, can affect this communication, using brain slices from young mice to better understand how we process sounds.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF DELAWARE (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-10426127 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms of how neurons release neurotransmitters, which are essential for communication between nerve cells. It focuses on the impact of various noise factors, such as the timing of electrical signals and the randomness of neurotransmitter release, on the effectiveness of this communication. By using advanced mathematical models and experimental techniques, the project aims to uncover how these factors influence the precision of neuronal responses. The research will involve studying brain slices from juvenile mice to gather data on synaptic transmission and its role in processing auditory information.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions affecting neuronal communication or auditory processing.
Not a fit: Patients with conditions unrelated to neuronal communication or those who are not experiencing auditory processing issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of neuronal communication, potentially informing treatments for neurological disorders.
How similar studies have performed: Similar research approaches have shown promise in understanding synaptic transmission, indicating that this project builds on established methodologies.
Where this research is happening
Newark, UNITED STATES
- UNIVERSITY OF DELAWARE — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SINGH, ABHYUDAI — UNIVERSITY OF DELAWARE
- Study coordinator: SINGH, ABHYUDAI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.