Understanding how neurons communicate and process signals
Regulation of axonal and synaptic signaling in interneurons
This study is looking at how brain cells work together to turn what we see and remember into actions, especially in young mice, to help us understand how these processes happen in the brain.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11073040 on NIH RePORTER |
What this research studies
This research investigates the specialized functions of neurons, particularly focusing on how they encode signals that translate sensory responses and memories into behavior. Using in vitro models, the team examines the roles of different parts of the neuron, such as dendrites and axons, in communication and signaling. The study aims to uncover how subthreshold signals and calcium release mechanisms influence neuronal excitation, especially in neonatal brains. By utilizing mouse models with fluorescent labeling, researchers can visualize and analyze the intricate signaling processes within living brain slices.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that affect neuronal signaling and communication.
Not a fit: Patients with purely psychological conditions unrelated to neuronal signaling may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of neuronal communication, potentially informing treatments for neurological disorders.
How similar studies have performed: Previous research has shown promising results in understanding neuronal signaling, making this approach a continuation of established scientific inquiry.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Trussell, Laurence O — Oregon Health & Science University
- Study coordinator: Trussell, Laurence O
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.