Understanding how neurons break down damaged mitochondria
Mechanistic investigation of in vivo pathways of neuronal mitochondrial degradation
This study is looking at how brain cells handle damaged energy sources called mitochondria, and it aims to understand how these cells can stay healthy and support each other, which could help us learn more about conditions that affect the brain.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-10816530 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which neurons degrade their mitochondria, which are crucial for their energy needs. It focuses on how neurons adapt to mitochondrial damage, particularly through a process called mitophagy, and how they may transfer damaged mitochondria to supportive glial cells for degradation. By studying these pathways in a natural nervous tissue environment, the research aims to uncover new insights into neuronal health and the impact of mitochondrial dysfunction on neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who may be experiencing neurodegenerative conditions related to mitochondrial dysfunction.
Not a fit: Patients with acute neurological injuries or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurodegenerative diseases by enhancing our understanding of mitochondrial degradation in neurons.
How similar studies have performed: While the specific pathways being investigated may be novel, previous research has shown that understanding mitochondrial function is critical in neurodegenerative disease contexts.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Insolera, Ryan — Wayne State University
- Study coordinator: Insolera, Ryan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.