Understanding how neurons and oligodendrocytes communicate to distribute myelin in the brain.
Neuron-oligodendrocyte communication underlying myelin distribution in the neocortex
This study is looking at how brain cells talk to each other to help protect nerve fibers, which is important for brain health, and it's for anyone interested in understanding how our brains work and heal.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard University NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10843198 on NIH RePORTER |
What this research studies
This research investigates the communication between neurons and oligodendrocytes, which are cells responsible for forming the myelin sheath around nerve fibers in the brain. By focusing on the neocortex, the study aims to uncover how different types of neurons influence the distribution and characteristics of myelin. Researchers will utilize advanced molecular profiling techniques to analyze the interactions between these cells and identify specific genes involved in this process. This knowledge could enhance our understanding of myelination and its implications for brain function and regeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 21 years old who may have conditions related to myelination or central nervous system function.
Not a fit: Patients with conditions unrelated to myelination or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into myelin-related disorders and potential therapeutic strategies for conditions affecting brain function.
How similar studies have performed: Previous research has shown promising results in understanding myelination processes, but this specific approach using CRISPR technology is relatively novel.
Where this research is happening
Cambridge, United States
- Harvard University — Cambridge, United States (Active)
Researchers
- Principal investigator: Arlotta, Paola — Harvard University
- Study coordinator: Arlotta, Paola
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.