Understanding how neuron production affects brain development and disorders
Nf2-dependent regulation of neuronal scaling in the developing cerebellum
This study is looking at how the brain makes different types of nerve cells in the cerebellum, which helps with balance and coordination, to better understand how problems in this process might lead to conditions like autism and ataxia, and it hopes to find new ways to help treat these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11112394 on NIH RePORTER |
What this research studies
This research investigates how different types of neurons are produced in the brain, focusing on the cerebellum, which is crucial for balance and coordination. It aims to understand the mechanisms that ensure the right number of neurons are formed, as disruptions in this process can lead to developmental disorders like autism and ataxia. By studying the interactions between specific neuron types, the research seeks to uncover how these cells communicate and regulate each other's growth. This could provide insights into potential therapeutic targets for conditions related to neuronal scaling.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with autism spectrum disorder or spinocerebellar ataxia.
Not a fit: Patients with unrelated neurological conditions or those not affected by developmental brain disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for developmental brain disorders, improving outcomes for affected patients.
How similar studies have performed: Other research has shown promising results in understanding neuronal development and its implications for brain disorders, indicating that this approach has potential for success.
Where this research is happening
Memphis, United States
- University of Tennessee Health Sci Ctr — Memphis, United States (Active)
Researchers
- Principal investigator: Chizhikov, Viktor — University of Tennessee Health Sci Ctr
- Study coordinator: Chizhikov, Viktor
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.