Understanding how neuron dysfunction leads to tau protein buildup in early Alzheimer's disease
Official title: Interneuron dysfunction and the emergence of tau pathology in early Alzheimer’s disease
Funded at Emory University · NIH-11018527 · Data updated 2026-11-12
This study is looking at how certain brain cells change early on in Alzheimer's disease, which could help us find new ways to treat the condition and improve care for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | December 6, 2023 |
| Project end | December 5, 2027 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 5F31AG086006-02 |
| Project ID | NIH-11018527 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or in the early stages of Alzheimer's disease, particularly those showing early signs of cognitive impairment.
✕Less likely to help
Patients with advanced Alzheimer's disease or those without any cognitive impairment may not benefit from this research.
What this research studies
This research investigates the early changes in brain activity associated with Alzheimer's disease, focusing on a specific type of neuron called parvalbumin-expressing interneurons. These neurons help regulate the balance of excitation and inhibition in the brain, and their dysfunction may contribute to the development of tau pathology before significant amyloid-beta accumulation occurs. By studying animal models of Alzheimer's, the research aims to uncover the mechanisms behind these early changes, which could lead to new therapeutic strategies. Patients may benefit from insights gained about the timing and nature of interventions for Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more effective treatments for Alzheimer's disease, potentially slowing or preventing cognitive decline.
How similar studies have gone: Previous studies have shown promising results in understanding early neuronal dysfunction in Alzheimer's, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Banks, Emmie — Emory University
- Study coordinator: Banks, Emmie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.