Understanding how neurofilaments behave in amyotrophic lateral sclerosis
Identifying mechanisms of neurofilament regulation and turnover in amyotrophic lateral sclerosis
This study is looking at how certain proteins called neurofilaments behave in people with ALS, with the hope of finding new ways to track the disease and see how well treatments are working.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10945644 on NIH RePORTER |
What this research studies
This research investigates the role of neurofilaments in amyotrophic lateral sclerosis (ALS), a severe neurodegenerative disease that leads to muscle weakness and respiratory failure. The team aims to identify how neurofilaments are regulated and how they change over time in ALS patients. By developing advanced assays to measure neurofilament levels and their modifications, the research seeks to improve the understanding of ALS progression and treatment response. This could help in identifying biomarkers that predict disease outcomes and treatment efficacy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with amyotrophic lateral sclerosis.
Not a fit: Patients with other neurodegenerative diseases or those without a diagnosis of ALS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatment strategies for patients with ALS.
How similar studies have performed: Previous research has shown promise in using neurofilament levels as biomarkers in neurodegenerative diseases, indicating that this approach has potential for success.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Ly, Cindy V — Washington University
- Study coordinator: Ly, Cindy V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.