Understanding how Neuritin-1 helps protect the brain from Alzheimer's disease
Official title: Defining the Neuroprotective Mechanisms of Neuritin-1 in Cognitive Resilience to Alzheimer's Disease
Funded at University of Alabama at Birmingham · NIH-10900324 · Data updated 2026-11-12
This study is looking at how a protein called Neuritin-1 might help keep the brains of people with Alzheimer's disease functioning well, even when there are signs of the disease, and it could lead to new ways to support brain health as we age.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $40,264 |
| NIH project number | 1F31AG084195-01A1 |
| Project ID | NIH-10900324 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 65 and over, particularly those showing early signs of Alzheimer's disease or cognitive decline.
✕Less likely to help
Patients under 65 years of age or those without any signs of cognitive impairment may not benefit from this research.
What this research studies
This research investigates the role of Neuritin-1 in promoting cognitive resilience in individuals with Alzheimer's disease (AD). By analyzing proteins associated with cognitive resilience, the study aims to uncover mechanisms that protect older adults from dementia despite the presence of AD pathology. The approach involves advanced mass spectrometry techniques to identify and validate proteins that may contribute to maintaining cognitive function. This research could lead to new therapeutic strategies for enhancing brain health in aging populations.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help preserve cognitive function in individuals at risk for Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in identifying neuroprotective mechanisms in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Pugh, Derian — University of Alabama at Birmingham
- Study coordinator: Pugh, Derian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.