Understanding how neural stem cells become active in the brain
Official title: Label-free, live-cell classification of neural stem cell activation state
Funded at University of Wisconsin-Madison · NIH-11126362 · Data updated 2026-11-12
This study is looking at how brain cells that help create new neurons work, especially as we age or deal with conditions like Alzheimer's, to find ways to boost brain health and improve thinking skills.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | June 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $629,031 |
| NIH project number | 1R01NS138454-01A1 |
| Project ID | NIH-11126362 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing cognitive decline or at risk for neurological diseases, particularly those related to aging.
✕Less likely to help
Patients with acute neurological conditions unrelated to neurogenesis or cognitive decline may not benefit from this research.
What this research studies
This research investigates the activation states of neural stem cells (NSCs) in the brain, which are crucial for generating new neurons throughout life. By using a novel technique called optical cell state imaging (OCSI), the study aims to identify the factors that influence NSC activation and quiescence, particularly in the context of aging and neurological diseases like Alzheimer's. The approach allows for non-invasive tracking of NSC states in living cells, providing insights into how these cells can be stimulated to promote neurogenesis and potentially improve cognitive function. Patients may benefit from a better understanding of how to enhance brain health and combat cognitive decline.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing neurogenesis and improving cognitive function in patients with neurological diseases.
How similar studies have gone: Other research has shown promise in using non-invasive imaging techniques to study cell behavior, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Moore, Darcie Leann — University of Wisconsin-Madison
- Study coordinator: Moore, Darcie Leann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.