Understanding how neural crest cells move and develop during embryonic growth
Dissecting single cell dynamics that coordinate neural crest migration and diversification
This study is exploring how certain cells in developing embryos, called neural crest cells, move and change into different types of cells, using zebrafish to help understand the process better, so we can learn more about how these important cells work during early development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11052514 on NIH RePORTER |
What this research studies
This research investigates the intricate processes of cell migration and differentiation in embryonic development, specifically focusing on neural crest cells. By utilizing gene expression profiling in single cells, zebrafish genetics, and computational modeling, the study aims to uncover how these cells coordinate their movement and development. The researchers will develop new methods to track individual cells and analyze the genes that regulate their adhesion and signaling. This multidisciplinary approach seeks to provide a deeper understanding of the mechanisms that govern cell behavior during critical stages of development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by birth defects or cancers that may involve neural crest cells.
Not a fit: Patients with conditions unrelated to neural crest cell development or migration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to advancements in understanding and potentially treating birth defects and cancers related to neural crest cell dysfunction.
How similar studies have performed: Other research has shown success in using similar approaches to study cell migration and differentiation, indicating a promising avenue for further exploration.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Schilling, Thomas F — University of California-Irvine
- Study coordinator: Schilling, Thomas F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.