Understanding how neural crest cells help the heart heal
Investigating the contributions of neural crest to adult regeneration
This study is looking at special cells in the heart that might help it heal after an injury, and it could lead to new treatments for people with heart problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project ID | NIH-10646192 on NIH RePORTER |
What this research studies
This research investigates the role of neural crest cells in the regeneration of the adult heart, particularly after injury. By examining these unique cells, which contribute to the heart's structure, the study aims to uncover how they can promote healing and repair. The research employs advanced techniques such as single-cell RNA sequencing and high-resolution imaging to analyze the behavior and gene expression of these cells during the regeneration process. Patients may benefit from insights gained into heart repair mechanisms that could lead to new treatments for heart conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have experienced heart injuries or conditions related to hypertrophic cardiomyopathy.
Not a fit: Patients with non-cardiovascular conditions or those under 21 years old may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that enhance heart regeneration and improve outcomes for patients with heart disease.
How similar studies have performed: Previous studies have shown promise in understanding cardiac regeneration, but the specific focus on neural crest-derived cells represents a novel approach.
Where this research is happening
Berkeley, United States
- University of California Berkeley — Berkeley, United States (Active)
Researchers
- Principal investigator: Martik, Megan Lee — University of California Berkeley
- Study coordinator: Martik, Megan Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.