Understanding how neural crest cells evolved in vertebrates
Progressive acquisition of novel neural crest derivatives along the neural axis during vertebrate evolution
This study looks at how certain cells in our bodies, which help form important structures like jaws, have changed over time in different types of animals, and it aims to help us understand more about how these changes can affect health and lead to birth defects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project ID | NIH-11065512 on NIH RePORTER |
What this research studies
This research investigates the evolution of neural crest cells, which are crucial for forming structures like jaws and peripheral ganglia in vertebrates. By comparing the genetic expression in jawed vertebrates and jawless lampreys, the study aims to uncover how these cells have developed unique functions over time. The researchers will analyze specific genes and their regulatory elements to understand the evolutionary changes that allowed for the formation of craniofacial structures. This work could provide insights into the fundamental biology of vertebrates and the origins of certain birth defects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to neural crest development, such as certain birth defects or tumors associated with neural crest cells.
Not a fit: Patients with conditions unrelated to neural crest development or those outside the age range of 21+ years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of vertebrate evolution and potentially inform strategies for addressing related birth defects.
How similar studies have performed: While this research explores novel aspects of neural crest evolution, similar studies have successfully identified key genetic factors in other developmental processes.
Where this research is happening
Pasadena, United States
- California Institute of Technology — Pasadena, United States (Active)
Researchers
- Principal investigator: Bronner, Marianne — California Institute of Technology
- Study coordinator: Bronner, Marianne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.