Understanding how neural activity affects brain and spinal cord development
Mechanisms of neural activity during neural tube formation
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-10756490
This study is looking into how certain medications for epilepsy taken during pregnancy might affect the development of the brain and spinal cord in babies, specifically focusing on how these drugs could lead to problems like neural tube defects.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-10756490 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind neural tube formation, a critical process in the development of the brain and spinal cord. It focuses on how certain factors, particularly the use of antiepileptic drugs during pregnancy, may lead to neural tube defects (NTDs). By studying the role of neurotransmitter signaling, specifically glutamate, in embryonic neural activity, the research aims to uncover the molecular pathways involved in this process. The approach includes using animal models to observe the effects of these drugs on neural development.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals who are taking antiepileptic medications or have a family history of neural tube defects.
Not a fit: Patients who are not pregnant or those who do not have a history of neural tube defects or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention of neural tube defects in newborns.
How similar studies have performed: Previous research has shown that understanding neurotransmitter signaling can lead to significant insights into developmental processes, suggesting potential for success in this area.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BORODINSKY, LAURA NOEMI — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: BORODINSKY, LAURA NOEMI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.