Understanding how Netrin proteins guide neuron growth and connections
Official title: Molecular and functional characterization of repulsive guidance by Netrin complexes
Funded at University of Chicago · NIH-11228219 · Data updated 2026-11-12
This study is looking at how special proteins called Netrins help guide the growth of nerve cells, which is important for making sure our brains are wired correctly, and it could help us understand problems that happen when those connections go wrong.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | May 26, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $481,126 |
| NIH project number | 1R01NS140594-01A1 |
| Project ID | NIH-11228219 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurodevelopmental disorders, such as autism spectrum disorder, who may benefit from advancements in understanding neural connectivity.
✕Less likely to help
Patients with neurodevelopmental disorders not related to neuronal wiring or those with purely genetic conditions may not receive direct benefits from this research.
What this research studies
This research investigates the role of Netrin proteins in guiding the growth of neurons, focusing on how these proteins can send both attractive and repulsive signals to developing axons. By studying the interactions between Netrin complexes and their receptors, particularly the UNC-5 receptor family, the research aims to uncover the mechanisms behind proper neural wiring. This could provide insights into neurodevelopmental disorders caused by incorrect neuron connections. The research employs various model organisms, including mammals and fruit flies, to explore these complex signaling pathways.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurodevelopmental disorders by improving our understanding of neuronal wiring.
How similar studies have gone: Previous research has shown promising results in understanding axon guidance mechanisms, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Ozkan, Engin — University of Chicago
- Study coordinator: Ozkan, Engin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.