Understanding how nerves interact with the knee joint
Mapping the joint-nerve interactome of the knee
['FUNDING_OTHER'] · RUSH UNIVERSITY MEDICAL CENTER · NIH-10861323
This study is looking at how the nerves in your knee might be linked to chronic low back pain and other joint issues, using advanced 3D models to better understand these connections and how they affect your overall joint health.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUSH UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10861323 on ClinicalTrials.gov |
What this research studies
This research investigates the complex interactions between nerves and the knee joint, focusing on how these connections may contribute to chronic low back pain and other joint disorders. By creating detailed 3D models and cell atlases, the team aims to profile the sensory nerve cells associated with the knee at a single-cell level. The study also explores the degeneration of intervertebral discs and facet joints, examining how these changes affect nerve function and pain perception. This comprehensive approach combines advanced techniques and expertise from multiple institutions to enhance our understanding of joint health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from chronic low back pain or knee joint disorders.
Not a fit: Patients with acute injuries or conditions unrelated to nerve interactions in the knee or lower back may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for chronic pain conditions related to the knee and lower back.
How similar studies have performed: Previous research has shown promise in understanding nerve interactions in other joints, suggesting that this approach could yield valuable insights.
Where this research is happening
CHICAGO, UNITED STATES
- RUSH UNIVERSITY MEDICAL CENTER — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MALFAIT, ANNE-MARIE — RUSH UNIVERSITY MEDICAL CENTER
- Study coordinator: MALFAIT, ANNE-MARIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.