Understanding how nerves control insulin release in diabetes and obesity
Neural control of pancreatic endocrine function in obesity and diabetes
This study is looking at how nerves in the pancreas help control insulin release, especially for people dealing with obesity and diabetes, to find new ways to improve blood sugar management.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10757034 on NIH RePORTER |
What this research studies
This research investigates the role of pancreatic nerves in regulating insulin release, particularly in the context of obesity and diabetes. By examining how a high-fat diet affects the structure and function of these nerves, the study aims to uncover new insights into their gene expression and overall impact on blood glucose control. The researchers will utilize advanced techniques such as 3D imaging and RNA sequencing to gain a detailed understanding of these neural pathways. This knowledge could lead to innovative approaches for diabetes treatment by targeting the neural control of insulin secretion.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with type 2 diabetes or those at risk of developing diabetes, particularly those with obesity.
Not a fit: Patients with type 1 diabetes or those whose diabetes is not influenced by pancreatic nerve function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diabetes that improve blood sugar control by targeting pancreatic nerve activity.
How similar studies have performed: While the specific approach of targeting pancreatic nerve activity in diabetes is relatively novel, similar research has shown promise in understanding neural control of metabolic processes.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Stanley, Sarah Amy — Icahn School of Medicine at Mount Sinai
- Study coordinator: Stanley, Sarah Amy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.