Understanding how nerves affect sweat gland development
Official title: Molecular mechanisms in sweat gland innervation
Funded at New York University School of Medicine · NIH-10882949 · Data updated 2026-11-12
This study is looking at how nerve signals help sweat glands grow and work, especially for people with severe burns or who were born without enough sweat glands, to find new ways to help them sweat better and stay cool.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 18, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $680,678 |
| NIH project number | 1R01AR082033-01A1 |
| Project ID | NIH-10882949 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with severe burn injuries or congenital conditions that impair sweat gland function.
✕Less likely to help
Patients without any issues related to sweat gland function or thermoregulation may not benefit from this research.
What this research studies
This research investigates the role of neuronal signals in the development of sweat glands, which are crucial for regulating body temperature and maintaining water balance. It focuses on patients with severe burn injuries or congenital sweat gland deficiencies who struggle with thermoregulation. By studying mouse models, the research aims to uncover the molecular mechanisms that govern sweat gland stem cell differentiation and maturation in response to nerve signals. The ultimate goal is to pave the way for potential therapies that could regenerate functional sweat glands in affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help patients with sweat gland deficiencies better regulate their body temperature.
How similar studies have gone: While the specific focus on neuronal influence in sweat gland development is relatively novel, related research has shown promise in understanding stem cell regeneration in other tissues.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Lu, Catherine Pei-Ju — New York University School of Medicine
- Study coordinator: Lu, Catherine Pei-Ju
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.