Understanding how nerve tumors develop in patients with neurofibromatosis type 1.
Developmental Origin, Injury and Epigenomic Regulation of NF1-Associated Peripheral Nerve Sheath Tumors
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11261453
This study is looking into how certain tumors called malignant peripheral nerve sheath tumors (MPNST) develop in people with neurofibromatosis type 1 (NF1), especially focusing on how benign tumors called plexiform neurofibromas can change into MPNSTs, and it hopes to find new treatments by understanding the early stages of nerve growth and the effects of nerve injuries.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11261453 on ClinicalTrials.gov |
What this research studies
This research investigates the origins and development of malignant peripheral nerve sheath tumors (MPNST) in individuals with neurofibromatosis type 1 (NF1). It focuses on the role of plexiform neurofibromas (PNFs), which are benign tumors that can progress to MPNSTs, and how nerve injury and genetic factors contribute to their formation. By studying the early stages of nerve development and the impact of nerve injury, the research aims to identify potential new therapies for treating these tumors. Patients may be involved in providing samples or data that can help advance understanding of this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neurofibromatosis type 1, particularly those with plexiform neurofibromas.
Not a fit: Patients without neurofibromatosis type 1 or those who do not have plexiform neurofibromas may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for treating malignant peripheral nerve sheath tumors in NF1 patients.
How similar studies have performed: While the specific approach of this research may be novel, there is ongoing interest in understanding the mechanisms of tumor development in NF1, suggesting potential for breakthroughs in treatment.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHU, YUAN — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: ZHU, YUAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.