Understanding how nerve signals affect immune responses in lymph nodes
Monitoring neurochemical signaling dynamics in the lymph node
This study is looking at how certain chemicals in your lymph nodes affect your immune system, especially during inflammation and autoimmune conditions, and it hopes to find new ways to improve treatments for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10906750 on NIH RePORTER |
What this research studies
This research focuses on exploring the neurochemical signaling that occurs within lymph nodes, which are crucial for immune function. By developing advanced tools to measure the release of specific neurochemicals like norepinephrine, ATP, and melatonin, the study aims to uncover how these signals influence immune responses during conditions such as inflammation and autoimmunity. Patients may benefit from this research as it seeks to enhance our understanding of the gut-immune system interactions and could lead to new therapies targeting these pathways. The research employs innovative electrochemical methods to capture rapid signaling dynamics in real-time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from autoimmune conditions or gastrointestinal disorders.
Not a fit: Patients with non-autoimmune related health issues or those not experiencing gastrointestinal problems may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better manage autoimmune diseases and gastrointestinal inflammation.
How similar studies have performed: While the approach of monitoring neurochemical signaling is innovative, similar studies have shown promise in understanding immune responses, suggesting potential for success.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Ross, Ashley E — University of Cincinnati
- Study coordinator: Ross, Ashley E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.