Understanding how nerve signals affect heart function after injury
Cardiac Neuromodulation: Mechanisms and Therapeutics
['FUNDING_P01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-10904652
This study is looking at how nerve damage affects heart health in people with chronic heart issues, and it hopes to find new ways to improve heart function and prevent serious heart problems through a treatment called vagal nerve stimulation.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10904652 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between the heart and the sympathetic nervous system in patients with chronic heart injuries. It aims to uncover how nerve damage alters neurotransmitter release, which can lead to dangerous heart rhythms. By exploring the effects of vagal nerve stimulation, the research seeks to identify potential therapeutic approaches to improve heart health and prevent sudden cardiac death. Patients may benefit from insights into new treatment strategies that target these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of heart injury or conditions that predispose them to arrhythmias.
Not a fit: Patients with no history of cardiac issues or those who do not experience arrhythmias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the risk of life-threatening heart arrhythmias.
How similar studies have performed: Previous research has shown promising results in neuromodulation therapies for heart conditions, suggesting that this approach may lead to significant advancements.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHIVKUMAR, KALYANAM — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: SHIVKUMAR, KALYANAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.