Understanding how nerve injuries affect muscle health
Identification and Imaging of Skeletal Muscle Response to Graded Nerve Crush
This study is looking at how nerve injuries affect muscle health, especially how they can lead to muscle wasting and scarring, and it's designed for anyone interested in understanding more about muscle recovery after nerve damage.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11292544 on NIH RePORTER |
What this research studies
This research investigates the impact of nerve injuries on skeletal muscle health, particularly focusing on muscle atrophy and fibrosis that can occur after such trauma. By using animal models, the study aims to assess the relationship between nerve damage and muscle function, specifically looking at the activity of a protein called calpain that is involved in muscle degradation. The researchers will employ advanced imaging techniques to dynamically evaluate muscle condition over time, providing insights that could improve clinical assessments of muscle injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced severe nerve injuries leading to muscle dysfunction.
Not a fit: Patients with muscle injuries not related to nerve damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools for assessing muscle damage after nerve injuries, ultimately improving recovery outcomes for patients.
How similar studies have performed: Previous research has shown promise in using similar imaging techniques to assess muscle conditions, indicating potential for success in this approach.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Brogan, David Micah — Washington University
- Study coordinator: Brogan, David Micah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.