Understanding how nerve injuries affect muscle health
Identification and Imaging of Skeletal Muscle Response to Graded Nerve Crush
['FUNDING_CAREER'] · WASHINGTON UNIVERSITY · NIH-10878833
This study is looking at how muscles react when nerves get hurt, especially focusing on certain proteins that can cause muscles to shrink, and it aims to find new ways to see how muscles are doing and healing after nerve injuries, which could help improve care for people with these kinds of injuries.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10878833 on ClinicalTrials.gov |
What this research studies
This research investigates how skeletal muscles respond to nerve injuries, particularly focusing on the role of specific proteins involved in muscle atrophy. By using animal models, the study aims to develop new techniques to assess muscle damage and recovery in real-time. Researchers will analyze the relationship between nerve injury and muscle function, measuring changes in muscle activity and the expression of key proteins. This could lead to better diagnostic tools for evaluating muscle health after nerve trauma.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced severe nerve injuries that may lead to muscle atrophy.
Not a fit: Patients with muscle atrophy not related to nerve injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for diagnosing and treating muscle atrophy following nerve injuries.
How similar studies have performed: Previous research has shown promise in using similar approaches to assess muscle health, but this specific method is relatively novel.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BROGAN, DAVID MICAH — WASHINGTON UNIVERSITY
- Study coordinator: BROGAN, DAVID MICAH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.