Understanding how nerve growth affects triple-negative breast cancer spread

Who could benefit from this research

What this research studies

This research investigates the role of sensory nerves in the spread of triple-negative breast cancer (TNBC), a particularly aggressive form of breast cancer. The study aims to uncover how increased nerve innervation in tumors contributes to metastasis, which is the spread of cancer to other parts of the body. By examining the TRPV1 channel on sensory nerves, the researchers hope to identify mechanisms that could be targeted to reduce cancer spread and improve patient outcomes. The approach includes co-culturing TNBC cells with sensory neurons to analyze changes in nerve growth and cancer cell behavior.

Why it matters

Where this research is happening

• Tufts University Boston
  Boston, United States Active

Researchers

• Principal investigator: Bloomer, Hanan Christopher — Tufts University Boston
• Study coordinator: Bloomer, Hanan Christopher

Related research

Other NIH-funded projects on the same topics.

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• Co-Targeting IL-6 and CDK4/6 to Prevent TNBC in Women Veterans

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  NIH research Baltimore VA Medical Center · Baltimore, United States · NIH-11608792

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  NIH research University of Louisville · Louisville, United States · NIH-11567535

• Dormancy in Triple-Negative Breast Cancer: How Liver and Skin Metastases Go Quiet or Reactivate

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  NIH research Massachusetts Institute of Technology · Cambridge, United States · NIH-11531542

• Rac-enhanced CAR-Macrophages against TNBC

  A new cell therapy approach uses engineered macrophages with a CAR and Rac2 activation to target and kill triple-negative breast cancer cells expressing CSPG4.

  NIH research University of Louisville · Louisville, United States · NIH-11520503

• A new peptide therapy to help treat metastatic triple-negative breast cancer

  A new peptide therapy called PEG-FUD is being tested to help treat metastatic triple-negative breast cancer by normalizing the tumor environment to improve treatment delivery.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11453153

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.