Understanding how nerve development affects bladder function in children
Neural crest-derived pelvic ganglia and the effects of developmental deficits on lower urinary tract innervation
['FUNDING_R01'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-11120958
This study is looking at how certain nerve cells help form the pelvic ganglia, which are important for controlling the bladder, to better understand why some children might have bladder problems, and it could lead to new treatments for these issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-11120958 on ClinicalTrials.gov |
What this research studies
This research investigates the role of neural crest progenitors in the development of pelvic ganglia, which are crucial for bladder control. By studying how these nerve cells differentiate and mature, the research aims to uncover the underlying mechanisms that may lead to bladder dysfunction in children. The approach involves using genetically modified mice to observe the effects of specific gene mutations on bladder innervation and function. Insights gained from this research could help in developing targeted therapies for urinary tract conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are children aged 0-11 years who experience bladder control issues.
Not a fit: Patients outside the age range of 0-11 years or those without bladder dysfunction may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for bladder dysfunction in children.
How similar studies have performed: Previous research has shown success in understanding nerve development and its impact on bladder function, making this approach promising.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SOUTHARD-SMITH, E MICHELLE — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: SOUTHARD-SMITH, E MICHELLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.