Understanding how nerve connections form and stop growing in tiny worms.
Mechanisms of synapse formation and axon termination in C. elegans
['FUNDING_R01'] · SEATTLE CHILDREN'S HOSPITAL · NIH-10984173
This study is looking at how nerve cells stop growing and connect with each other, using tiny worms to learn more about the proteins that help with this process, which could eventually lead to better treatments for conditions like Alzheimer's disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SEATTLE CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10984173 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind how axons, the long projections of nerve cells, stop growing and form connections called synapses. Using the model organism C. elegans, the study focuses on specific proteins that regulate these processes, which are crucial for building a functional nervous system. By employing advanced techniques like mass spectrometry and CRISPR/Cas9 gene editing, researchers aim to uncover the molecular pathways involved in these critical functions. The findings could lead to new insights into treating neurodevelopmental and neurodegenerative disorders, including Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research would include individuals with neurodegenerative diseases, particularly Alzheimer's disease.
Not a fit: Patients with acute neurological injuries or those not affected by neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies for neurodegenerative diseases, improving outcomes for patients with conditions like Alzheimer's.
How similar studies have performed: Other research has shown promising results in understanding synapse formation and axon regulation, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
SEATTLE, UNITED STATES
- SEATTLE CHILDREN'S HOSPITAL — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GRILL, BROCK — SEATTLE CHILDREN'S HOSPITAL
- Study coordinator: GRILL, BROCK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease