Understanding how nerve connections form and stop growing in tiny worms.
Mechanisms of synapse formation and axon termination in C. elegans
This study is looking at how nerve cells grow and connect with each other using tiny worms called C. elegans, and the findings could help develop new treatments for conditions like Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10867472 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the growth termination of axons and the formation of synapses, which are crucial for building a functional nervous system. By studying the nematode C. elegans, researchers aim to uncover the molecular and cellular processes involved in these phenomena. The study employs advanced techniques such as high-sensitivity mass spectrometry and CRISPR/Cas9 gene editing to explore the role of specific proteins in regulating these processes. Insights gained could lead to new therapies for neurodevelopmental and neurodegenerative disorders, including Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by neurodegenerative diseases, particularly Alzheimer's disease.
Not a fit: Patients with acute neurological injuries or conditions unrelated to neurodegeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for neurodegenerative diseases like Alzheimer's, improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding synapse formation and axon growth, suggesting that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Grill, Brock — Seattle Children's Hospital
- Study coordinator: Grill, Brock
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.