Understanding how nerve connections develop and repair
Molecular genetics of axon and synapse development and maintenance
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11067778
This study looks at how nerve connections grow and heal in tiny worms called C. elegans, which could help us understand similar processes in humans, especially for those interested in nerve-related conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11067778 on ClinicalTrials.gov |
What this research studies
This research investigates the fundamental mechanisms of axon and synapse development and maintenance using the model organism C. elegans. By employing advanced imaging techniques, the study aims to observe and analyze the dynamic processes of synapse regulation and axon regeneration in living organisms. The research focuses on the locomotor circuit of C. elegans, allowing for detailed insights into how nerve connections are formed and repaired, which could have implications for understanding similar processes in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to nerve damage or those interested in the biological mechanisms of nerve regeneration.
Not a fit: Patients with non-neurological conditions or those not affected by axonal injuries may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for promoting nerve repair and recovery in patients with axonal injuries.
How similar studies have performed: Previous research using C. elegans has successfully identified key pathways involved in axon regeneration, indicating that this approach has a strong foundation in scientific literature.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JIN, YISHI — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: JIN, YISHI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: axon injury, axonal injury