Understanding how nerve cells respond to long-term loss of myelin support
Neuronal responses to chronic demyelination
This study is looking at how the loss of important support cells in the brain affects nerve cells, especially in conditions like multiple sclerosis, to see if the nerve cells can still survive and adapt when they don't have enough help.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11015838 on NIH RePORTER |
What this research studies
This research investigates the effects of chronic demyelination on neurons, particularly focusing on how the loss of oligodendrocytes, which are crucial for myelination, impacts nerve cell health and function. Using specialized mouse models, the study aims to observe neuronal responses to severe demyelination and determine whether neurons can survive or adapt to these conditions. By examining the mechanisms involved, the research seeks to provide insights into the relationship between oligodendrocyte support and axonal health, which is particularly relevant for conditions like multiple sclerosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with demyelinating conditions such as multiple sclerosis.
Not a fit: Patients with non-demyelinating neurological conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies aimed at protecting nerve cells in demyelinating diseases.
How similar studies have performed: Previous research has shown promising results in understanding neuronal responses to demyelination, but this specific approach using conditional knockout mouse models is relatively novel.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Emery, Ben — Oregon Health & Science University
- Study coordinator: Emery, Ben
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.