Understanding how nerve cells repair themselves after injury
Destabilization of axonal mRNAs by KHSRP complexes during axon regeneration
This research looks at how nerve cells control the building blocks they need to regrow after an injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Carolina at Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11144278 on NIH RePORTER |
What this research studies
Nerve cells, or neurons, need to repair themselves after an injury, like in a spinal cord injury or stroke. This project explores how these cells manage the genetic instructions (mRNAs) that tell them which proteins to make for repair and growth. We are focusing on a specific protein called KHSRP, which helps decide how long these instructions are available. By understanding how KHSRP affects the stability of these instructions, we hope to find new ways to encourage nerve regeneration.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients but aims to understand basic mechanisms relevant to those with nerve injuries or neurodegenerative conditions.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that help nerve cells regrow and repair themselves more effectively after injury or disease.
How similar studies have performed: This research builds upon previous findings that show the importance of specific proteins in regulating nerve cell growth and repair.
Where this research is happening
Columbia, United States
- University of South Carolina at Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Twiss, Jeffery L — University of South Carolina at Columbia
- Study coordinator: Twiss, Jeffery L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.