Understanding how nerve cells recycle signals and manage membrane tension
Dynamics of membrane tension and synaptic vesicle recycling
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11058444
This study is looking at how nerve cells send and recycle important chemicals that help them communicate, focusing on how the stretching of their outer layer affects this process, and it's designed for anyone interested in understanding how our nervous system works better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11058444 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which nerve cells release and recycle neurotransmitters at synapses, focusing on the role of membrane tension in these processes. By using advanced techniques like optical tweezers and electrophysiology, the study aims to measure membrane tension in large nerve terminals from fish neurons. This approach allows researchers to explore how changes in membrane tension affect the release and retrieval of neurotransmitters, which is crucial for proper nerve function. The findings could provide insights into the fundamental processes of cell communication in the nervous system.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that affect synaptic function, such as epilepsy or neurodegenerative diseases.
Not a fit: Patients with purely psychological conditions or those without neurological symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of synaptic function and potentially lead to new treatments for neurological disorders.
How similar studies have performed: While the specific approach of measuring membrane tension in synaptic terminals is novel, related research has shown success in understanding synaptic mechanisms and neurotransmitter dynamics.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KARATEKIN, ERDEM — YALE UNIVERSITY
- Study coordinator: KARATEKIN, ERDEM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.