Understanding how nerve cells maintain their shape and function
Mechanisms that control neuronal microtubule polarity
This project looks at how the internal structures of nerve cells are organized, which is important for keeping them healthy and helping them repair themselves.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project ID | NIH-11144934 on NIH RePORTER |
What this research studies
This research explores the tiny internal structures within nerve cells, called microtubules, which are crucial for their long-term health and ability to regrow after injury. We know that certain signals, called Wnt proteins, help create new microtubules in specific parts of nerve cells. This project aims to understand how these signals from surrounding cells might guide the organization of microtubules within nerve cells. Using advanced genetic tools in fruit flies, we are learning how nerve cells build and maintain their unique shapes and connections. This work could reveal new ways to protect nerve cells and help them recover from damage.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future studies building on this work might seek individuals with neurological conditions involving nerve damage or degeneration.
Not a fit: Patients will not receive direct medical benefit from participating in this basic science project, as it focuses on fundamental biological mechanisms.
Why it matters
Potential benefit: If successful, this basic science could lead to new ways to protect nerve cells and help them regenerate after injury or disease.
How similar studies have performed: Previous work has shown that Wnt signaling proteins play a role in controlling microtubule nucleation in dendrites, providing a foundation for this expanded investigation.
Where this research is happening
University Park, United States
- Pennsylvania State University, the — University Park, United States (Active)
Researchers
- Principal investigator: Rolls, Melissa — Pennsylvania State University, the
- Study coordinator: Rolls, Melissa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.