Understanding how nerve cells interact with skin in health and disease
Official title: Sensory neuron-skin interaction in health and disease
Funded at Ohio State University · NIH-11023148 · Data updated 2026-11-12
This study is looking at how nerve cells and skin cells work together and how this affects pain that some cancer patients feel after chemotherapy, with the hope of finding better ways to prevent and treat that pain.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | February 1, 2024 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $125,442 |
| NIH project number | 5K01AR080833-03 |
| Project ID | NIH-11023148 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients experiencing chemotherapy-induced peripheral neuropathy.
✕Less likely to help
Patients who are not undergoing chemotherapy or do not experience neuropathic pain may not benefit from this research.
What this research studies
This research investigates the interactions between sensory neurons and skin cells, particularly focusing on how these interactions contribute to neuropathic pain caused by chemotherapy. By using both human and animal models, the research aims to uncover the mechanisms behind chemotherapy-induced peripheral neuropathy (CIPN), which affects a significant number of cancer patients. The study employs advanced techniques to explore how changes in the skin environment and nerve cell behavior can lead to pain, with the goal of identifying new prevention and treatment strategies for CIPN.
Why it matters
Potential benefit: If successful, this research could lead to effective treatments for neuropathic pain in cancer patients undergoing chemotherapy.
How similar studies have gone: Previous research has shown promise in understanding nerve-skin interactions, but this specific approach to CIPN is innovative and largely untested.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Shin, Grace Ji-Eun — Ohio State University
- Study coordinator: Shin, Grace Ji-Eun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.